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Fallout 4 The Cabot House Guide: Kill or Free Lorenzo?

| November 30, 2015

Fallout 4 The Cabot House Guide: Kill or Free Lorenzo? GameGuides  Fallout Guide Fallout 4 Fallout

Fallout 4 is full of tons of interesting side quests and adventures. It also has a few moments where the morality of your actions really comes into question. These two elements combine in the excellent mission “The Cabot House”. This multi-part side quest culminates in a truly difficult decision for the player, which can have a bit of a lasting impact on their Fallout 4 experience. Rather than walk through every step of The Cabot House mission, this guide will focus on just the end of it, which is really the only difficult and morally grey part. So, with full spoiler warning in place, here’s all the info to help you decide whether to kill or free Lorenzo in The Cabot House mission of Fallout 4.

After storming the Parsons State Insane Asylum, killing dozens of Raiders and reaching the basement, the player will be face-to-face with Lorenzo Cabot. The patriarch of the Cabot family has been imprisoned in this cell for over 400 years, with an alien artifact keeping him alive and supplying his children with a “Mysterious Serum” that has kept them alive. You now are faced with a choice though, do you trust Jack Cabot and kill his father, or do you set him free?

The consequences of each action are felt throughout Fallout 4. Morally you’ll have some trouble either way. It’s obvious that keeping Lorenzo locked up is wrong, but was there any other choice? Killing him will likely cause trouble with any companion you have with you, but the actions after might be far worse. Let’s break down exactly what happens with each choice.

If you kill Lorenzo, which you do by flipping the four switches on the walls, you head back to Cabot House with Jack where he give you about 500 caps. If you were kind to him throughout the mission, he will tell you to come back in a week. You can use sleep and wait to make the time pass faster if you need to, or just keep playing and let the week pass by. The mission will update once it has, so you’ll know when to head back.

Once there Jack will give you Lorenzo’s Artifact Gun, which is a Gamma Gun with a special modification. This gun does a decent amount of damage, but its true value is in the various effects of the modification. It can stagger enemies and will deal damage in different ways depending on certain factors. Overall there are better weapons out there, but it could be useful in a few situations.

Now, if you decide to free Lorenzo the mission becomes a whole other affair. Lorenzo will then ask if you wish to help him kill his family. Again, be careful what companion you have here as there’s a lot of morally grey actions going on. Whatever you tell Lorenzo here isn’t totally important, just head back to Cabot House for the rest of the mission.

Once there you are presented with the opportunity to switch allegiances once again. If you side with Jack and the rest of the Cabot family you’ll have a very tough fight against Lorenzo (use the Mysterious Serum you found at the asylum to make it much easier). At the end you’ll get the caps, but not the gun.

If you stick with Lorenzo you’ll assist in killing the Cabot family, which should be pretty easy, especially if you convince Edward to join your side. Once it’s over Lorenzo will give you about 500 caps and explain the new deal. At any time you can swing by the Cabot House to grab more Mysterious Serum. You can only ever have one vial at a time, which cannot be traded or sold. Once it’s used just head back and grab some more.

This serum gives you a huge Strength boost, as well as a ton of damage resistance and rad resistance. It could be pretty useful out in the wasteland of Fallout 4, so if you are willing to slaughter a not so innocent family this could be the best option. Just have Piper or Curie head to one of your settlements before the fighting begins.

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  • Needle Mag

    I did this one. Freed Lorenzo, then headed back and. somehow, sided with Jack, even though I didn’t realize that was what I was doing. Before I knew it, Lorenzo was killing us all. I tiny nuked him a couple times, sent some 10mm into his skull, then walked over the corpses of nearly the entire family to get back to Jack yelling at me about ruining everything. I pretty much did all the things wrong in this one. Sorry, Cabots.

    • Beamzers

      When I was in the chamber where he was locked up I accidently opened his doors and let him out and then he mentions meeting him back at the house to kill his family. I wasn’t too keen on that idea so I loaded from a previous save point and helped kill him in his cell. After he was dead I went inside hoping to take the artifact off his head but it wouldn’t let me.

    • Nathan Fleming

      Same here and to think i could have saved Edward

      • Ophelia Meadows

        It’s a little late for this but you can save Edward anyway. If you go through some various dialog options (I was right starts them up) you can pass a speech check to convince him that Jack and the rest of the Cabots are wrong. He will then side with you and Lorenzo and when its over he will say “It’s a shame it had to end this way.” and walk off.

  • jrwolfmusic

    Kill Lorenzo. Then make sure to open his cell and clear it out. Tons of food and a surgical journal. Sleep in the bed if you want.

  • Alficus Edwards

    i freed him and piper got all pissed off and left after i killed all the cabots

  • emmanouil

    Freed Lorenzo, talked to him and then killed him (crippled right arm, used some stimpaks), not so difficult with a maximized laser rifle.
    Then returned to Cabot family, told them Lorenzo was dead, The End.

  • Archer Sterling

    I freed him and killed him once his back was turned. Then I beat his body and Curie fell in love with me as I pummeled his corpse.

    • George Joseph McTernan

      LANAAAAA look at this corpse! It’s…so weird looking.

  • Chris Brink

    I let him out, then joined jack in killing him. As long as no family members die, you still get the gun. Otherwise jacks all butthurt n bids u good day.

    • Craig Spokane

      How did you kill him? He’s pretty high level.

      • Yamakaziku

        Took me a few tries to figure or the best way. First few times i tried hitting him with the wounding fat man which did like absolutely nothing to his health bar, even with a mysterious serum and psychojet. Easiest way by far was just to use the serum plus however many psychojets back to back, when they stop slowing time, and shoot him repeatedly with the wounding maximized institute rifle or your choice of a good dps weapon. Only took two psychojets and wham. The real trick is killing him quick before he kills a family member.

        • Bnan

          Lol just placed two live frags in his pocket and the deal was done

  • Mengus Dew

    I only keep Dogmeat by my side

    • Bailey McBride

      Got to love the Lone Wanderer perk.

      • Madi

        First what I did was remember this spot then kill other things then level up and get the best killing perk

  • NickB

    I freed him, killed the cabots, and am enjoying using the mysterious syrum

    BUT: I ran into him out in the common wealth later, and he had 3-4 dead bodies around him. Has anyone else seen this?

    • Madi


    • Stuart Funkasaurus Mcwilliam

      Wow really. I’ll keep an eye out haha

    • davepak

      yes, he randomly kills people for “experiments” or something like this. its confirmation that it was a bad idea (story wise) to side with him.

    • Darkstar9445

      Yes, at a random location he has 3-4 dead ghoul settlers around him and tells the Sole Survivor that he killed them to study their condition.

    • Barry Allen

      ok….so freeing lorenzo WAS a bad idea…..turns out he was an asshole

  • AlucardVX

    Having Ada from Automatron as companion is a great plus. She’ll not complain the massacre at all, but Lorenzo giving just one Mysterious Serum at a time, it’s just annoying.

  • PJBean

    MacCready doesn’t care at all if he dies >:D

  • iQillU

    I just went through the mission and thought it should be noted that in the quarentine chamber outside lorenzos holding cell are 3 viles of the syrum sitting on a tray. It was much easier to kill lorenzo after noticing this;)
    (Also there is a surgical journal inside of lorenzos actual holding cell as well as in Jacks room at the Cabot house)
    ((And a zeta gun on his desk in the lab))
    Have fun!

  • Stuart Funkasaurus Mcwilliam

    I freed Lorenzo, still had no idea what was going on. Everyone was pissed, killed the family, got the lifetime worth of serum and the gun and caps. Also raided the house. There was some good stuff in there. Hahaha also I had Nick, he didn’t seem to care. Much of a muchness this mission.

    • Zane Ward

      and that sir, is the way it’s done ;) ….you only have to have saved emogene (jacks sister) to have free reign of the house (take whatever you want), it’s already empty before i even went to the asylum have 2 zeta guns now, cause i leave nada behind, stole the first one, later (much later) after starting the mission to go to asylum there was another one (weeks of ingame time had pased after saving jacks sister btw) and freely took the second one at the point jack waits outside to go to asylum…. as for the rest… who DOESN’T search everything and take everything? :D

      good game mate

  • Sarinzi

    Chose to kill Lorenzo after reading this. Turns out Hancock admires and likes that decision.

  • Eva-X

    I killed Lorenzo the first chance I got. I was contemplating freeing him but I wanted his suit/headpiece pretty badly so I killed him for it. Too bad I could only take the suit though.

  • LeemondtheFirst

    Yeah, Macready ‘liked that’ when I pulled all four switches.

  • louis8291

    I freed him then joined Jack emogene died but I still found the gamma gun laying around in a back room.

  • This was one of the toughest dilemmas I think I’ve faced as a “good” character in a game, because Jack makes it VERY clear that he’s going to kill Lorenzo. Eventually, I decided to help Jack kill Lorenzo. Now I’ve read this article, it’s clear I made the right moral choice, as any other decision kills more people.

  • Jordan Phillipson

    I freed Lorenzo and killed the family but looted the gun off jacks body but didn’t receive any caps

  • Ophelia Meadows

    It’s a little late for this but you can save Edward anyway. If you go through some various dialog options (I was right starts them up) you can pass a speech check to convince him that Jack and the rest of the Cabots are wrong. He will then side with you and Lorenzo and when its over he will say “It’s a shame it had to end this way.” and walk off.