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Image of the player close to the Diamond city area within Fallout 4 wielding a boxing glove next to a statue.
Image: Attack of the Fanboy

Fallout 4: The Secret of Cabot House Best Ending

Fallout 4 has many quests which require you to make significant choices, and one of these quests is The Secret of Cabot House where you will eventually need to decide what to do with Lorenzo.

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This article will take you through whether you should kill or free Lorenzo in Cabot House.

Should You Kill or Free Lorenzo in Fallout 4?

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Image: Attack of the Fanboy

We recommend killing Lorenzo at the end of the quest because you will get the Artifact Gun, which is an excellent weapon and and won’t be available elsewhere. If the loot is all you care about, killing Lorenzo is probably your best choice.

However, if you feel guilty killing a character who has been locked away, then your moral reasoning may push you to the other option. If you decide to free Lorenzo, you’ll have access to the Mysterious Serum, but there’s more. Lorenzo might become a danger to the Wasteland, using abilities like mind control and energy beam to spread chaos and create all sorts of trouble.

What Happens If You Kill Lorenzo?

If you kill Lorenzo, which you do by flipping the four switches on the walls, you head back to Cabot House with Jack where he gives you about 500 caps. If you were kind to him throughout the mission like I was, he will tell you to come back in a week. You can use sleep and wait to make the time pass faster if you need to, or just keep playing and let the week pass by. The mission will update once it has, so you’ll know when to head back.

Once there, Jack will give you Lorenzo’s Artifact Gun, a Gamma Gun with a special perk. This gun does a decent amount of damage, but its true value is in the various effects of the mod. It can stagger enemies and will deal damage in different ways depending on certain factors. It’s one of the best weapons in Fallout 4, and I’ve found it can help you get through plenty of sticky situations.

The Artifact Gun

The Artifact Gun is a unique radiation weapon you get during a the Secret of Cabot House quest. Unlike most radiation weapons, it does not irradiate the targets hit by its ammo and can hurt enemies immune to radiation damage.

Artifact Gun FeaturesDetails
Base Damage25 radiation + 10 energy damage
EffectKnocks back and stuns enemies
Ammo TypeGamma Rounds
Fire Rate66
Range203
Accuracy69
Weight4.5
Value753 caps
ModificationsVarious mods that enhance damage, range, and stagger effect
Unique PerkArtifact Gun’s knockback and stun effect is unique and powerful for crowd control

What Happens If You Free Lorenzo?

If you decide to free Lorenzo, the mission becomes a whole other affair. Once free, Lorenzo will ask if you wish to help him kill his family. Again, be careful what companion you have here as there are a lot of morally grey actions going on. Whatever you tell Lorenzo here isn’t important; just head back to Cabot House for the rest of the mission.

Once there, you are then presented with the opportunity to switch allegiances. If you side with Jack and the rest of the Cabot family, you’ll have a very tough fight against Lorenzo (use the Mysterious Serum you found at the asylum to make it much easier). In the end, you’ll get the caps, but not the gun.

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Image: Attack of the Fanboy

If you stick with Lorenzo like I didn’t do, you’ll assist in killing the Cabot family, though it should be pretty easy, especially if you convince Edward to join your side. Once it’s over, Lorenzo will give you about 500 caps and explain the new deal. You can swing by the Cabot House to grab more Mysterious Serum at any time. You can only ever have one vial at a time, which cannot be traded or sold. Once it’s used, just head back and grab some more.

This serum gives you a considerable Strength boost, as well as a ton of damage resistance and rad resistance. I have found it to be greatly useful throughout the game, so there is no harm in going with this route. If you are willing to slaughter a not-so-innocent family, this could be the best option. Just have Piper or Curie head to one of your settlements before the fighting begins.

That said, you should keep in mind that siding with Lorenzo will cause many problems to the residents of the Wasteland.

Is Lorenzo Evil in Fallout 4?

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Yes, we believe that Lorenzo is evil. If he gets out and isn’t killed, there have been reports of players noticing Lorenzo going on murdering sprees across the wasteland in a serial killer-like fashion. This is not the sign of a morally sane man — rather the opposite — so killing him and acquiring the Artifact Gun isn’t too bad an outcome.

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Lorenzo may or may not be behaving rationally, but that hardly matters when he’s blasting people and using his mind control abilities with little regard for the consequences. Whether he’s truly crazy or justified matters little if you also care about the safety of the people in the Wasteland.

Can You Get Lorenzo’s Helmet?

It is not possible to get Lorenzo’s Helmet by normal methods in Fallout 4. However, if you are playing on a PC, then you can easily use console commands to acquire and equip the helmet.

The name of the headpiece is Lorenzo’s Crown, and to bring up console commands, you need to press the “~” key. When you do, type: “player.additem 001467F5” and then confirm that with the enter key.

You will now have Lorenzo’s Crown in the game, but to equip it, you will need to type “player.equipitem 001467F5” and then enter. Now you can happily go around the Wasteland with a brilliant fashion sense on display.

If you want something more immersive, there’s a change you can find some mod that allows you to acquire his helmet without the need of console commands.

Are There Any Other Ways to Deal With Lorenzo in Fallout 4?

No, you only get two choices to deal with Lorenzo and that will come down to what you think is best. We have explained the reasoning behind each choice, so hopefully, that will allow you to make an easier decision — The Cabot House certainly has a lot of morality involved.

Whether you decide to free or kill Lorenzo, we know that you will make the choice that matters the most to you similar to the Pickman’s Gift quest.


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Gordon Bicker
Gordon is a contributing writer for Attack of the Fanboy, a Games Design (BA) Honours student, and a Video Game Ambassador. He has been writing at AOTF for over a year and a half, with four years of games writing experience for outlets like Green Man Gaming. When he's not busy, he'll no doubt be experiencing games, writing poetry, playing guitar, adventuring, or happily starting a new Skyrim playthrough! As an avid Final Fantasy XIV player, he also hopes that you'll gain a warm feeling from his community stories. Gordon has reported on Fallout 4 and Destiny 2, whose favorite genres include action RPGs, MMORPG's and First Person Shooters but is always experimenting with many other types of games.
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Diego Perez
Currently serving as an Associate Editor at Attack of the Fanboy, Diego Perez has been writing about video games since 2018, specializing in live service games like Destiny and Final Fantasy XIV. His work is featured at publications like Game Rant and The Outerhaven, but Attack of the Fanboy is home to his best work. When he's not editing or writing guides, he's yelling about Ape Escape or grinding Lost Sectors in Destiny. Plus, he has a Bachelor of Science in Telecommunication Media Studies for Texas A&M University.
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Davi Braid
Davi Braid is a Staff Writer for Attack of the Fanboy with a passion for storytelling. He has been a full-time writer for the past 5 years. His work spans RPGs, Fighting Games, and many other genres, showcasing his versatility and broad interests. With a degree in International Relations, his writing has been published across various outlets and niches. Leaving a traditional office job, he built a career as a writer, embracing new genres and discovering hidden gems in gaming.